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Smart Physical-Based Transdermal Drug Delivery System:Towards Intelligence and Controlled Release
Haojie Zhang1, Yinping Pan1, Yao Hou1
1Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.
Small (Weinheim an Der Bergstrasse, Germany)
|October 18, 2023
Summary
Smart transdermal drug delivery systems leverage physical principles for enhanced disease therapy. This review highlights intelligent designs for real-time monitoring and precise drug release, advancing personalized medicine and smart medical devices.
Area of Science:
- Materials Science and Engineering
- Biomedical Engineering
- Pharmaceutical Sciences
Background:
- Traditional transdermal drug delivery systems (TDDS) offer stable, efficient, and safe disease therapy.
- Limitations exist in real-time control and precise drug release, hindering optimal treatment efficacy and patient compliance.
- The need for intelligent devices is paramount for advanced therapeutic applications.
Purpose of the Study:
- To review recent advancements in smart transdermal drug delivery systems (sTDDS) based on physical principles.
- To explore application scenarios, drug release characteristics, and intelligent design concepts in physical-based TDDS.
- To highlight physical enhancement strategies for improved transdermal effects and the development of smart medical devices.
Main Methods:
- Comprehensive literature review of physical principle-based smart transdermal drug delivery technologies.
- Analysis of intelligent design concepts for real-time monitoring and precise drug release.
- Examination of physical enhancement techniques in combination with pharmaceutical dosage forms.
Main Results:
- Significant progress in smart TDDS utilizing physical principles for enhanced drug delivery.
- Demonstrated potential for real-time monitoring and precise control of drug release.
- Physical enhancement strategies show promise for improved transdermal absorption and therapeutic outcomes.
Conclusions:
- Smart physical-based TDDS represent a significant advancement in disease therapy and personalized medicine.
- Future directions include integration into smart medical devices for improved clinical treatment.
- Emerging applications in vaccine delivery and tumor treatment are highly promising.
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