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TRPM channels in health and disease

Vladimir Chubanov1, Michael Köttgen2,3, Rhian M Touyz4

  • 1Walther-Straub Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany. vladimir.chubanov@lrz.uni-muenchen.de.

Nature Reviews. Nephrology
|October 18, 2023
PubMed

Insights

Transient Receptor Potential Melastatin (TRPM) channels regulate cation levels and are vital for kidney function. Dysregulation of TRPM channels is linked to kidney diseases, making them potential therapeutic targets.

Area of Science:

  • Molecular Biology
  • Physiology
  • Nephrology

Background:

  • Cellular cation homeostasis is critical for preventing human diseases, particularly those affecting the kidneys.
  • Melastatin-related transient receptor potential (TRPM) channels (TRPM1-TRPM8) are key regulators of cation transport.
  • TRPM channels are implicated in various physiological processes and are abundant in the kidney.

Purpose of the Study:

  • To provide an overview of TRPM channel research.
  • To delineate the role of TRPM channels in kidney pathophysiology.
  • To highlight TRPM channels as potential therapeutic targets for kidney diseases.

Main Methods:

  • Literature review of TRPM channel functions and roles in kidney disease.
  • Analysis of TRPM channel expression and mutations in human genetic disorders.
  • Examination of preclinical studies on TRPM channels in animal models of kidney disease.

Main Results:

  • TRPM channels exhibit diverse ion selectivity (divalent, non-selective, monovalent cations) and some possess enzymatic activity.
  • TRPM channels are involved in mineral homeostasis, blood pressure, immunity, and sensory perception.
  • Mutations in TRPM genes are associated with inherited diseases, and TRPM channels are implicated in kidney pathophysiology.

Conclusions:

  • TRPM channels are crucial for kidney function and homeostasis.
  • Dysregulation of TRPM channels contributes to kidney diseases.
  • TRPM channels represent promising therapeutic targets for treating kidney disorders.

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