Related Experiment Video

Updated: Jul 13, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.6K

Abdominal aortic calcification in patients newly diagnosed with essential thrombocythemia

Myung-Won Lee1, Jeong Suk Koh1, Sora Kang1

  • 1Division of Hematology/Oncology, Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.

Blood Research
|October 18, 2023
PubMed

Insights

Abdominal aortic calcification (AAC) is prevalent in essential thrombocythemia (ET) patients and linked to arterial thrombotic events. This finding highlights AAC as a significant risk factor in ET, emphasizing the need for its assessment at diagnosis.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Radiology

Background:

  • Atherosclerosis is implicated in arterial thrombotic events in essential thrombocythemia (ET).
  • Abdominal aortic calcification (AAC) has been understudied in ET patients.
  • This study investigated the prevalence and clinical significance of AAC at ET diagnosis.

Purpose of the Study:

  • To determine the prevalence of abdominal aortic calcification (AAC) in newly diagnosed essential thrombocythemia (ET) patients.
  • To identify risk factors associated with AAC in ET.
  • To evaluate the association between AAC and arterial thrombotic vascular events in ET.

Main Methods:

  • Retrospective analysis of 94 newly diagnosed ET patients who underwent abdominal computed tomography (CT) between 2002 and 2021.
  • Quantitative assessment of abdominal aortic calcification (AAC) using CT imaging.
  • Statistical analysis to identify risk factors and associations with thrombotic events.

Main Results:

  • Abdominal aortic calcification (AAC) was detected in 66.0% of ET patients.
  • Old age, higher white blood cell count, elevated neutrophil-to-lymphocyte ratio, and JAK2V617F positivity were associated with AAC.
  • AAC was an independent risk factor for arterial thrombotic vascular events occurring before or at the time of ET diagnosis.

Conclusions:

  • Abdominal aortic calcification (AAC) is common in patients with essential thrombocythemia (ET).
  • AAC is significantly associated with arterial thrombotic events in ET patients.
  • Assessment of AAC may be valuable for risk stratification in ET.
Abstract

Keywords:
Abdominal aortic calcificationArterial thrombosisAtherosclerosisEssential thrombocythemia

More Related Videos

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

3.4K
A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

3.9K

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
19
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
10
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
11
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
9
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
14
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
9