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Area of Science:

  • Gerontology
  • Molecular Biology
  • Cardiovascular Health

Background:

  • Leukocyte telomere length (LTL) serves as a biomarker for biological aging.
  • The relationship between LTL and dyslipidemia, an aging-related disease, requires further longitudinal investigation.
  • Previous studies predominantly utilized cross-sectional designs.

Purpose of the Study:

  • To examine the longitudinal association between dyslipidemia and changes in LTL over time.
  • To investigate the impact of specific blood lipid levels on telomere length alterations.
  • To explore age-related differences in this association.

Main Methods:

  • A cohort of 1624 individuals in rural China underwent two data collection rounds, 9.8 years apart.
  • Relative telomere length (RTL) was measured using real-time quantitative PCR.
  • Multiple linear regression and generalized linear models analyzed the association between dyslipidemia, lipid levels, and RTL changes.

Main Results:

  • 83.3% of participants showed telomere length reduction; 16.7% showed an increase.
  • Dyslipidemia at baseline or follow-up was associated with increased longitudinal changes in LTL, notably in healthy individuals aged ≥60.
  • Lower HDL-C levels correlated with greater longitudinal changes in LTL.

Conclusions:

  • Telomere length changes are significantly correlated with dyslipidemia and its components, especially HDL-C.
  • Sustained dyslipidemia and declining HDL-C may contribute to accelerated telomere attrition.
  • These findings highlight the interplay between metabolic health and cellular aging.