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Intradermal Low-Fat Spindle Cell Lipoma: A Case Report
Hyeong Mok Kwon1, Jung Eun Yim1, Hye Ri Kim1
1Department of Dermatology, Yeungnam University College of Medicine, Daegu, Korea.
Annals of Dermatology
|October 19, 2023
Summary
This study reports an extremely rare case of intradermal low-fat spindle cell lipoma, a benign skin neoplasm. The findings highlight its unique presentation and histopathological features for accurate diagnosis.
Area of Science:
- Dermatopathology
- Surgical Pathology
- Oncology
Background:
- Spindle cell lipoma (SCL) is a rare, benign mesenchymal neoplasm typically found in subcutaneous tissue.
- Intradermal SCL is exceptionally rare, posing diagnostic challenges due to overlapping features with other skin tumors.
Observation:
- A 46-year-old female presented with a 6-year-history of a 0.7-cm flesh-colored, dome-shaped nodule on her right temple.
- Histopathological examination revealed an unencapsulated dermal lesion with bland spindle cells, scant adipocytes, and prominent myxoid stroma.
Findings:
- Immunohistochemical analysis showed CD34 positivity, S-100 protein negativity, and loss of retinoblastoma protein expression.
- The diagnosis of intradermal low-fat spindle cell lipoma was confirmed, with no recurrence observed 4 months post-excision.
Implications:
- This case underscores the rarity of intradermal SCL and the importance of comprehensive histopathological and immunohistochemical evaluation.
- Accurate diagnosis is crucial to differentiate SCL from other neoplasms with similar clinical and histological presentations, ensuring appropriate patient management.
