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Superficial CD34-Positive Fibroblastic Tumor: Two Case Reports
Jung Eun Yim1, Hyeong Mok Kwon1, Hye Ri Kim1
1Department of Dermatology, Yeungnam University College of Medicine, Daegu, Korea.
Annals of Dermatology
|October 19, 2023
Summary
Superficial CD34-positive fibroblastic tumor (SCPFT) is a rare neoplasm. This report details two new cases in Korea, aiding in its understanding and differentiation from other soft tissue tumors.
Area of Science:
- Dermatopathology
- Surgical Pathology
- Oncology
Background:
- Superficial CD34-positive fibroblastic tumor (SCPFT) is a rare, recently described fibroblastic neoplasm.
- Characterized by nuclear pleomorphism, low mitotic activity, and diffuse CD34 positivity.
- Fewer than 50 cases reported globally.
Observation:
- Two new cases of SCPFT in young males involving the thigh.
- Histopathology revealed spindle-to-epithelioid cells with pleomorphic nuclei and glassy cytoplasm.
- Immunohistochemistry confirmed diffuse CD34 positivity and negativity for S100, SMA, and desmin.
Findings:
- Both patients underwent successful wide excision.
- No recurrence or metastasis observed during follow-up periods of 16 and 11 months.
- These represent the first reported cases of SCPFT in Korea.
Implications:
- These case reports expand the understanding of SCPFT's clinicopathological features.
- Aids in differentiating SCPFT from other superficial soft tissue neoplasms.
- Highlights the importance of immunohistochemistry in diagnosis.
