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Levosimendan improves cardiac function, hemodynamics, and body inflammation in patients with acute myocardial

Xiaoxia Sun1, Congying Wei2, Lei Li1

  • 1Cardiovascular Division, Xianyang First People's Hospital No. 10, Biyuan Road, Qindu District, Xianyang 712000, Shaanxi, China.

American Journal of Translational Research
|October 19, 2023
PubMed

Insights

Levosimendan improves cardiac function and reduces inflammation in acute myocardial infarction patients with heart failure. This treatment shows higher effectiveness and safety compared to conventional methods.

Area of Science:

  • Cardiology
  • Pharmacology
  • Critical Care Medicine

Background:

  • Acute myocardial infarction (AMI) complicated with heart failure (HF) presents significant challenges in patient management.
  • Hemodynamic instability and systemic inflammation are key pathophysiological features in these patients.

Purpose of the Study:

  • To evaluate the efficacy and safety of levosimendan in patients with AMI and concurrent HF.
  • To assess the impact of levosimendan on cardiac function, hemodynamics, and inflammatory markers.

Main Methods:

  • A retrospective analysis of 113 patients with AMI and HF was performed.
  • Patients were divided into a control group (conventional therapy) and an observation group (levosimendan plus conventional therapy).
  • Cardiac function (LVEF), hemodynamic parameters (PAMP, PCWP), and inflammatory markers (hs-CRP) were compared before and after treatment.

Main Results:

  • The levosimendan group demonstrated a significantly higher overall response rate compared to the control group.
  • Improvements in cardiac function, pulmonary arterial pressure, and C-reactive protein levels were more pronounced in the levosimendan group.
  • The levosimendan group experienced fewer adverse reactions and better quality of life after six months.

Conclusions:

  • Levosimendan is effective in improving cardiac function, hemodynamics, and reducing inflammation in patients with AMI and HF.
  • The addition of levosimendan to conventional therapy offers a favorable safety profile and enhances patient outcomes.
  • Diabetes and specific treatment regimens were identified as independent factors influencing treatment efficacy.
Abstract

Keywords:
Acute myocardial infarctionbody inflammation levelcardiac functionheart failurehemodynamicslevosimendan

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