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Predictive value of serum human epididymis protein 4 for heart failure in patients with chronic kidney disease

Cunyuan Dong1, Shujuan Feng2, Haiqian Ma2

  • 1Department of Nuclear Medicine, Zhangjiakou First Hospital Zhangjiakou 075000, Hebei, China.

American Journal of Translational Research
|October 19, 2023
PubMed

Insights

Human epididymis protein 4 (HE4) can predict heart failure in chronic kidney disease (CKD) patients. Elevated HE4 levels indicate a higher risk of developing heart failure, making it a valuable biomarker.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarker Discovery

Background:

  • Chronic kidney disease (CKD) is associated with an increased risk of heart failure (HF).
  • Identifying reliable biomarkers for early HF detection in CKD patients is crucial for timely intervention.

Purpose of the Study:

  • To evaluate the predictive value of human epididymis protein 4 (HE4) for the development of heart failure in patients with CKD.

Main Methods:

  • Retrospective analysis of 241 CKD patients.
  • Comparison of baseline data and hematologic indicators between heart failure (HF) and non-HF groups.
  • Univariate, correlation, and multivariate logistic regression analyses were performed.

Main Results:

  • Patients with HF had significantly higher serum creatinine, HE4, and B-type natriuretic peptide (BNP) levels.
  • HE4, age, TG, and BNP were significantly correlated with HF occurrence.
  • Multivariate analysis confirmed HE4 as a significant predictor of HF in CKD patients (P<0.01), with risk increasing above HE4 > 27.2368 pmol/L.

Conclusions:

  • Human epididymis protein 4 (HE4) is a significant predictor of heart failure in CKD patients.
  • Higher serum HE4 levels are associated with an increased likelihood of developing heart failure.
Abstract

Keywords:
Serum human epididymis protein 4chronic kidney diseaseheart failurepredictive value

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