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Erythema multiforme provoked by radiotherapy.

Natalia Joanna Machoń1, Julia Alicja Lewandowska1, Joanna Chojnacka-Purpurowicz2

  • 1Medical Faculty University of Warmia and Mazury Olsztyn Poland.

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|October 19, 2023
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Summary

Radiation therapy can cause a rare, widespread skin reaction resembling erythema multiforme. This study highlights the importance of considering radiation as a trigger for such dermatological adverse effects in cancer patients.

Keywords:
HSVerythema multiformelaryngeal cancerradiodermatitis

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Area of Science:

  • Dermatology
  • Oncology
  • Radiation Oncology

Background:

  • Radiation dermatitis is a common side effect of radiation therapy, typically localized to the irradiated area.
  • Generalized skin lesions are less common but have been reported.
  • Erythema multiforme-like lesions represent a rare but significant cutaneous manifestation.

Observation:

  • A 63-year-old patient presented with disseminated erythematous lesions on the trunk and extremities.
  • The patient was undergoing radiotherapy treatment and denied new medications or supplements.
  • The patient received a combination of oral and intravenous corticosteroids, acyclovir, and topical treatments.

Findings:

  • The patient's skin condition showed significant improvement after one month of treatment.
  • This case suggests a link between radiation therapy and erythema multiforme-like eruptions.
  • Prompt dermatological evaluation and treatment led to positive patient outcomes.

Implications:

  • Radiation therapy should be considered a potential trigger for erythema multiforme-like lesions in cancer patients.
  • Early recognition and management of these adverse skin reactions are crucial for patient well-being.
  • This finding contributes to understanding the spectrum of cutaneous side effects associated with oncological treatments.