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Updated: Jul 12, 2025
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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
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Optimizing cognitive and behavioral approaches for perinatal depression: A systematic review and meta-regression
Ahmed Waqas1, Syeda Wajeeha Zafar2, Parveen Akhtar3
1Department of Primary Care & Mental Health, Institute of Population Health, University of Liverpool, Liverpool, UK.
Global Mental Health (Cambridge, England)
|October 19, 2023
Summary
Cognitive behavioral therapies (CBT) effectively treat perinatal depression (PND). This meta-analysis confirms CBT
Area of Science:
- Psychiatry and Behavioral Sciences
- Clinical Psychology
- Perinatal Health
Background:
- Perinatal depression (PND) is a significant concern affecting maternal mental health.
- Cognitive behavioral therapies (CBT) are recognized for their efficacy in treating PND.
- Existing meta-analyses provide evidence, but updated, comprehensive reviews are needed to refine understanding of CBT's effectiveness and mechanisms.
Purpose of the Study:
- To provide up-to-date meta-analytical evidence on the effectiveness of CBT for treating and preventing PND.
- To critically synthesize psychotherapy approaches within a precision medicine framework, exploring mechanisms of action and identifying optimal approaches for specific populations.
- To delineate the effectiveness and moderators of CBT interventions for PND through meta-regression analyses.
Main Methods:
- A systematic review and meta-regression analysis of 56 studies identified through searches of six academic databases up to February 2022.
- Extraction of patient-level and intervention-level characteristics and effect size data using pretested sheets.
- Random-effects meta-analyses and mixed-effect subgroup analyses were conducted to assess effectiveness and identify moderators.
Main Results:
- CBT-based interventions demonstrated a strong effect size (SMD = -0.74) in alleviating depressive symptoms in perinatal populations.
- Effectiveness was consistent across various delivery formats (individual, group, electronic) and providers (specialists, nonspecialists).
- Intervention duration did not appear to be a critical factor for effectiveness; incorporating diverse behavioral components is recommended.
Conclusions:
- CBT is a highly effective intervention for perinatal depression, offering robust symptom alleviation.
- The versatility of CBT delivery formats and providers supports its broad applicability.
- Future CBT interventions for PND should focus on integrating a range of behavioral strategies to maximize therapeutic benefits.
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