Psychometric Properties of the Persian Version of Cystic Fibrosis Questionnaire: Revised in Children with Cystic
Naser Havaei1, Mohammad Reza Modaresi2, Mandana Rezaei3
1Occupational Therapy Department, Faculty of Rehabilitation Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Insights
The Persian Cystic Fibrosis Questionnaire-Revised (CFQ-R) child and parent versions are valid and reliable for assessing quality of life in children with cystic fibrosis. Using both versions together offers a comprehensive understanding of patient well-being.
Area of Science:
- Pediatric Health
- Psychometrics
- Quality of Life Measurement
Background:
- Cystic fibrosis (CF) is a progressive, fatal genetic disease impacting patients' quality of life.
- The Cystic Fibrosis Questionnaire-Revised (CFQ-R) is a validated tool for monitoring health-related quality of life (HRQoL) in CF patients.
- Assessing HRQoL is crucial for comprehensive CF patient care and clinical trial evaluation.
Purpose of the Study:
- To evaluate the psychometric properties of the Persian translation of the child and parent versions of the CFQ-R.
- To establish the validity and reliability of the Persian CFQ-R for use in the Iranian pediatric CF population.
- To determine the suitability of the Persian CFQ-R for clinical trials and patient monitoring.
Main Methods:
- Methodological study involving 50 children with CF (aged 6-11) and their parents.
- Assessment of convergent validity, discriminant validity, test-retest reliability (n=30), internal consistency, and ceiling/floor effects.
- Examination of agreement between child and parent proxy versions of the Persian CFQ-R.
Main Results:
- Convergent validity was confirmed (P < 0.05).
- The CFQ-R effectively discriminated between disease severity stages based on lung function, age, and BMI (P < 0.05).
- Test-retest reliability was good to excellent (ICC = 0.78–0.97), with generally confirmed internal consistency (α = 0.13–0.87).
- Parent proxy versions reported lower HRQoL scores than child versions in most domains (P < 0.05).
- No floor effects were observed; ceiling effects were noted in specific domains for both versions.
Conclusions:
- The Persian child and parent CFQ-R versions are valid and reliable instruments for measuring HRQoL in Iranian children with CF.
- These validated tools can be utilized in clinical trials to monitor the quality of life in pediatric CF patients.
- Concomitant use of both child and parent versions is recommended for a more thorough interpretation of HRQoL aspects in children with CF.
Background:
Cystic fibrosis is a progressive, fatal disease affecting the quality of life. The cystic fibrosis questionnaire-revised (CFQ-R) is an efficient tool to monitor health-related quality of life in patients. The aim of this study was to explore the psychometric properties of the child and parent versions of the Persian version of the CFQ-R in the Iranian population.
Methods:
Fifty children with cystic fibrosis (6-11 years) and their parents were allocated in this methodological study to examine convergent validity, discriminant validity, test-retest reliability (n = 30), internal consistency, ceiling and floor effects, and agreement between two versions of the CFQ-R.
Results:
Convergent validity was confirmed for parent proxy (P < 0.05). CFQ-R discriminated patients among stages of disease severity based on lung function, age, and BMI (P < 0.05). Test-retest analysis revealed good to excellent reliability (inter-class correlation coefficient (ICC) = 0.78-0.97). In most domains, lower quality of life scores was obtained in the parent proxy compared to the child version (P < 0.05). Domain-specific correlations were found between the child version and parent proxy (P < 0.05). Internal consistency was generally confirmed (α = 0.13-0.83 in child version and α = 0.25-0.87 in parent proxy). There were no floor effects. Ceiling effects were mostly seen for physical, digestion, and body image domains in the child version and for eating, weight, and school domains in the parent proxy.
Conclusions:
The child version and parent proxy of the Persian CFQ-R are valid and reliable measures and can be applied in clinical trials to monitor the quality of life in children with cystic fibrosis. It is recommended to use both versions in conjunction to better interpret the quality of life aspects of children with cystic fibrosis.
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