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Related Experiment Video

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A phantom for targeted endomyocardial biopsy training.

Jacqueline Contento1, Vincent Cleveland1, Tina Ehtiati2

  • 1Division of Pediatric Cardiology, Children's National Hospital, Washington, District of Columbia, USA.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|October 19, 2023
PubMed
Summary

This study introduces a 3D printed phantom and biplane overlay technology to improve targeted endomyocardial biopsies (EMB) for conditions like cardiac allograft rejection and heart failure.

Keywords:
3D printingcardiac biopsyheart transplantoverlay technologytraining phantom

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Area of Science:

  • Cardiovascular Medicine
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Endomyocardial biopsy (EMB) of the right ventricular (RV) septum is crucial for diagnosing cardiac allograft rejection, heart failure, and cardiomyopathies.
  • Current EMB techniques lack precise targeting, potentially leading to suboptimal tissue sampling.

Purpose of the Study:

  • To develop and validate a novel methodology for targeted EMB using a 3D printed phantom and biplane overlay technology.
  • To assess the feasibility of performing targeted biopsies in specific regions of the RV septum.

Main Methods:

  • A 3D printed phantom simulating the RV septum was created.
  • Biplane overlay technology was employed to guide a standard bioptome and steerable sheath.
  • Feasibility of biopsy was tested across seven distinct RV septal regions using the developed system.

Main Results:

  • The study demonstrated the proof of concept for using biplane overlay technology with a 3D phantom for targeted EMB.
  • The methodology proved feasible for sampling multiple regions within the RV septum.

Conclusions:

  • A novel 3D printed phantom and biplane overlay system can enhance the precision of endomyocardial biopsies.
  • This technology holds potential for improving diagnostic accuracy and training for EMB in cardiac transplant and cardiomyopathy patients.