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Published on: June 5, 2021
Integrating SARS-CoV-2-specific interferon-γ release assay testing in the evaluation of patients hospitalized with
Mar Masiá1,2,3, Alba de la Rica1,4, Marta Fernández-González1,2
1Infectious Diseases Unit, Hospital General Universitario de Elche , Alicant, Spain.
Importance:
The cellular immune response is essential in the protection against severe disease in patients with established SARS-CoV-2 infection. The novelty of this study lies in the evaluation of the overall performance of a standardized assay to measure cellular immune response, the SARS-CoV-2-specific interferon-γ release assay (IGRA), in hospitalized patients with severe COVID-19. The SARS-CoV-2 IGRA was shown to accurately classify patients based on disease severity and prognosis, and the study revealed that test performance was not affected by the SARS-CoV-2 variant or control tube results. We identified an assay cut-off point with a high negative predictive value against mortality. The SARS-CoV-2 IGRA in patients hospitalized for COVID-19 may be a useful tool to assess cellular immunity and adopt targeted therapeutic and preventive measures.
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