Related Experiment Video
Updated: Jul 12, 2025
09:10
A Highly Scalable Approach to Perform Ecological Surveys of Selfing Caenorhabditis Nematodes
Published on: March 1, 2022
2.6K
CaeNDR, the Caenorhabditis Natural Diversity Resource
Timothy A Crombie1,2, Ryan McKeown2,3, Nicolas D Moya4,5
1Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL, USA.
Nucleic Acids Research
|October 19, 2023
Summary
The Caenorhabditis Natural Diversity Resource (CaeNDR) now supports quantitative genetics and genomics across three Caenorhabditis species. This updated platform provides expanded genetic data and tools for studying natural variation and trait evolution.
Area of Science:
- Genomics
- Quantitative Genetics
- Evolutionary Biology
Background:
- Model organisms are crucial for understanding genetic variation's role in trait diversity.
- The Caenorhabditis elegans Natural Diversity Resource (CeNDR) has been instrumental in facilitating genetic studies.
- Advances in genomics and experimental toolkits accelerate discoveries in natural populations.
Purpose of the Study:
- To introduce an updated platform, the Caenorhabditis Natural Diversity Resource (CaeNDR), for quantitative genetics and genomics.
- To expand research capabilities to include three Caenorhabditis species: C. elegans, C. briggsae, and C. tropicalis.
- To provide enhanced tools and data for exploring natural genetic variation and conducting genome-wide association (GWA) studies.
Main Methods:
- Development and expansion of a centralized database for wild Caenorhabditis strains.
- Integration of whole-genome sequence data and annotated variants for multiple species.
- Implementation of interactive tools for data exploration and GWA mapping.
Main Results:
- The CaeNDR platform now encompasses C. elegans, C. briggsae, and C. tropicalis.
- Databases are continuously updated with new strains, sequence data, and variants.
- New interactive tools facilitate natural variation analysis and GWA mapping.
Conclusions:
- CaeNDR provides a comprehensive, freely accessible resource for the Caenorhabditis research community.
- The platform significantly enhances the ability to study natural genetic variation and its phenotypic consequences across related species.
- CaeNDR is poised to drive future discoveries in quantitative genetics and evolutionary genomics.
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