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Diverse Research Teams and Underrepresented Groups in Clinical Studies
Ashank Bains1, Pawarissara Osathanugrah2, Nayan Sanjiv2
1Department of Ophthalmology, University of Washington, Seattle.
JAMA Ophthalmology
|October 19, 2023
Summary
Minority patients and those with lower socioeconomic status were less likely to join ophthalmic clinical trials. Matching patient and staff race/ethnicity increased enrollment, highlighting the need for diverse research teams.
Area of Science:
- Ophthalmology
- Clinical Research
- Health Equity
Background:
- Ophthalmic diseases disproportionately affect minority populations.
- Clinical trials often lack demographic representation due to recruitment barriers.
- Historical mistrust and cultural differences impact participation.
Purpose of the Study:
- To investigate the association between patient and research personnel demographics and consent rates in ophthalmic clinical studies.
- To identify factors influencing participation in eye disease research.
Main Methods:
- Retrospective cohort study of patients approached for ophthalmic clinical trials (2015-2021).
- Used multivariable logistic regression to analyze consent rates based on demographics.
- Included 1380 patients from an urban academic hospital.
Main Results:
- Black and Hispanic/Latino patients were less likely to consent compared to White patients.
- Lower socioeconomic status was associated with decreased consent rates.
- Racial and ethnic concordance between patients and research staff increased odds of consent.
Conclusions:
- Underrepresented racial/ethnic groups and lower socioeconomic status individuals are less likely to participate in ophthalmic studies.
- Diverse research teams, with shared racial/ethnic concordance, can improve participant enrollment.
- Increasing diversity in clinical research is crucial for equitable representation.
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