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Stereotactic radiosurgery for orbital cavernous hemangiomas.

You-Cong Chen1,2, Chieh-Chih Tsai2,3, Shih-Jen Chen2,3

  • 11Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

Journal of Neurosurgery
|October 19, 2023
PubMed
Summary

Single-session Gamma Knife radiosurgery (GKRS) is a safe and effective treatment for orbital cavernous hemangiomas (OCHs), leading to significant tumor regression and improved vision. This study confirms GKRS efficacy in OCH management.

Keywords:
Gamma Knifehemangiomaorbitalprogression-free survivalstereotactic radiosurgery

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Ophthalmology

Background:

  • Orbital cavernous hemangiomas (OCHs) are benign vascular tumors that can cause visual impairment.
  • Treatment options for OCHs have historically been limited, with surgery often posing risks.
  • Gamma Knife radiosurgery (GKRS) offers a non-invasive alternative for OCH treatment.

Purpose of the Study:

  • To evaluate the safety and efficacy of single-session Gamma Knife radiosurgery (GKRS) for treating orbital cavernous hemangiomas (OCHs).
  • To assess long-term outcomes, including tumor regression and visual function, after GKRS for OCHs.

Main Methods:

  • A single-center cohort study included 23 patients with OCHs treated with single-session GKRS between 1999 and 2022.
  • Patients received a median margin dose of 12 Gy.
  • Clinical and radiological follow-ups were conducted for a median of 45 months.

Main Results:

  • Tumor regression was observed in 95.7% of patients, with a mean relative volume reduction of 82.6%.
  • Significant improvements in visual acuity (69.2% of affected patients) and visual field deficits (62.5% of affected patients) were noted.
  • No adverse radiation effects were reported during the follow-up period.

Conclusions:

  • Single-session Gamma Knife radiosurgery (GKRS) is a safe and effective treatment for orbital cavernous hemangiomas (OCHs).
  • GKRS demonstrates a high rate of tumor regression and leads to substantial improvements in visual function.
  • Long-term follow-up confirms the sustained efficacy and safety of GKRS for OCH management.