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Updated: Jul 12, 2025
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Stereotactic radiosurgery for orbital cavernous hemangiomas
You-Cong Chen1,2, Chieh-Chih Tsai2,3, Shih-Jen Chen2,3
11Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Objective:
The goal of this study was to assess the safety and efficacy of single-session Gamma Knife radiosurgery (GKRS) for orbital cavernous hemangiomas (OCHs).
Methods:
Patients who presented with an OCH between September 1999 and May 2022 and were treated with single-session GKRS were included in this single-center cohort study.
Results:
There were 23 patients (7 males and 16 females) in this study. The median margin dose was 12 Gy (range 11-13 Gy). The median clinical and radiological follow-ups were 45 months (range 5-190 months) and 45 months (range 6-190 months), respectively. Nine (69.2%) of 13 patients with visual acuity impairment had improvement in best corrected visual acuity. Of the 8 patients with visual field defects, 5 patients (62.5%) had complete resolution. Tumor regression was observed in 22 patients (95.7%). The mean relative reduction in tumor volume was 82.6% ± 23.7%. The relative reductions in tumor volume were 33%, 49%, 72%, 84%, and 89% at 6, 12, 24, 36, and 48 months, respectively. Adverse effects of radiation were not observed.
Conclusions:
GKRS appears to be safe and efficacious for treating OCHs over long-term follow-up. The treatment is associated with a high rate of regression in OCHs and remarkable improvement in both visual acuity and visual field deficits.
Insights
Single-session Gamma Knife radiosurgery (GKRS) is a safe and effective treatment for orbital cavernous hemangiomas (OCHs), leading to significant tumor regression and improved vision. This study confirms GKRS efficacy in OCH management.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Ophthalmology
Background:
- Orbital cavernous hemangiomas (OCHs) are benign vascular tumors that can cause visual impairment.
- Treatment options for OCHs have historically been limited, with surgery often posing risks.
- Gamma Knife radiosurgery (GKRS) offers a non-invasive alternative for OCH treatment.
Purpose of the Study:
- To evaluate the safety and efficacy of single-session Gamma Knife radiosurgery (GKRS) for treating orbital cavernous hemangiomas (OCHs).
- To assess long-term outcomes, including tumor regression and visual function, after GKRS for OCHs.
Main Methods:
- A single-center cohort study included 23 patients with OCHs treated with single-session GKRS between 1999 and 2022.
- Patients received a median margin dose of 12 Gy.
- Clinical and radiological follow-ups were conducted for a median of 45 months.
Main Results:
- Tumor regression was observed in 95.7% of patients, with a mean relative volume reduction of 82.6%.
- Significant improvements in visual acuity (69.2% of affected patients) and visual field deficits (62.5% of affected patients) were noted.
- No adverse radiation effects were reported during the follow-up period.
Conclusions:
- Single-session Gamma Knife radiosurgery (GKRS) is a safe and effective treatment for orbital cavernous hemangiomas (OCHs).
- GKRS demonstrates a high rate of tumor regression and leads to substantial improvements in visual function.
- Long-term follow-up confirms the sustained efficacy and safety of GKRS for OCH management.
