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Neuronal γ-secretase regulates synaptic functions via cholesterol homeostasis

Wing-Yu Fu1, Amy K Y Fu2, Nancy Y Ip2

  • 1Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China; Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong, China.

Neuron
|October 19, 2023
PubMed
Summary

γ-secretase (gamma-secretase) regulates human neuron synapse formation and neurotransmission. Reduced activity boosts synapse creation but impairs neurotransmitter release, potentially by affecting cholesterol.

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