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Updated: Jul 12, 2025

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
Published on: June 1, 2019
Our house believes that: The clipped lymph node is the true sentinel node after neoadjuvant chemotherapy in N+
Benigno Acea-Nebril1, Alejandra García-Novoa1, Alberto Bouzón Alejandro1
1General Surgey Department, Breast Unit, University Hospital of A Coruña, Spain.
Abstract:
Axillary staging is an important prognostic factor in breast cancer, being sentinel lymph node biopsy (SLNB) the gold standard staging method in early stages. However, in clinically node positive (cN+) patients who converted to clinically node-negative (cN0) after primary systemic therapy (PST) the axillary staging method during surgery remains controversial. There are at least three validated methods: SLNB, targeted axillary dissection (TAD) and marking axillary nodes with radioactive iodine seeds (MARI) procedure. Our house believe that the biopsied and clipped lymph node could predict response to systemic treatment.

