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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

459
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
459
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

536
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
536

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Related Experiment Video

Updated: Jul 12, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Early Vitrectomy for Endophthalmitis: Are EVS Guidelines Still Valid?

Parsa Panahi1,2, Nasser Mirzakouchaki-Borujeni3, Omid Pourdakan4

  • 1Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran.

Ophthalmic Research
|October 19, 2023
PubMed
Summary

Early vitrectomy shows promise for endophthalmitis, but more research is needed. Current guidelines may not reflect modern clinical practice for all endophthalmitis types.

Keywords:
EVS guidelinesEndophthalmitisVitrectomy

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Area of Science:

  • Ophthalmology
  • Infectious Diseases

Background:

  • Endophthalmitis poses a significant threat to vision globally.
  • The 1995 Endophthalmitis Vitrectomy Study (EVS) established treatment guidelines for post-cataract surgery endophthalmitis.
  • Evolving clinical practices question the current applicability of EVS recommendations.

Purpose of the Study:

  • To review the current role of vitrectomy in managing endophthalmitis.
  • To assess the applicability of the Endophthalmitis Vitrectomy Study (EVS) guidelines in contemporary practice.
  • To explore the need for updated treatment strategies for various endophthalmitis types.

Main Methods:

  • Review of recent studies on early and complete vitrectomy (CEVE) for endophthalmitis.
  • Analysis of the limitations of existing research compared to the EVS.
  • Examination of evidence for vitrectomy in post-intravitreal injection, post-traumatic, and endogenous endophthalmitis.

Main Results:

  • Recent studies suggest early and complete vitrectomy (CEVE) may be effective regardless of initial visual acuity.
  • The rigor of recent studies may not match the EVS, warranting cautious interpretation.
  • The EVS focused solely on post-cataract surgery, leaving other endophthalmitis types without clear guidelines.

Conclusions:

  • Tailored treatment strategies are necessary, with early vitrectomy supported when clinically indicated.
  • Prospective trials are needed to clarify the role of early vitrectomy in diverse endophthalmitis scenarios.
  • Advancements in surgical techniques and antimicrobial therapies necessitate reevaluation of treatment paradigms for better ocular health outcomes.