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Bakuchiol modulates acetylcholine synthesis and alleviates Aβ proteotoxicity
Sachin Ranjan1,2, Shalini Trivedi1, Shruti Sharma1
1Ageing Biology Lab, Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India.
Natural Product Research
|October 19, 2023
Summary
Bakuchiol, a molecule from Psoralea corylifolia, enhances acetylcholine transmission, reduces oxidative stress, and extends lifespan. It modulates key genes involved in neural transmission and reduces harmful amyloid β and lipid levels.
Area of Science:
- Neuroscience
- Pharmacology
- Natural Products Chemistry
Background:
- Acetylcholine (ACh) transmission is vital for cognitive functions like memory and learning.
- Cholinergic dysfunction is implicated in various neurological disorders.
- Nootropic phytomolecules offer a promising therapeutic avenue for enhancing ACh levels.
Purpose of the Study:
- To identify and characterize an active phytomolecule for enhancing ACh transmission.
- To investigate the effects of Bakuchiol on ACh levels, oxidative stress, and lifespan.
- To elucidate the molecular mechanisms underlying Bakuchiol's neuroprotective effects.
Main Methods:
- Identification of Bakuchiol from Psoralea corylifolia.
- Assay of ACh transmission and reactive oxygen species (ROS) levels.
- Analysis of mRNA expression for genes involved in cholinergic pathways (choline transporter, choline acetyltransferase, acetylcholine transporter).
- Assessment of amyloid β and lipid levels, and gene expression of hsf-1 and lgg-1.
Main Results:
- Bakuchiol significantly elevated ACh transmission and reduced ROS levels.
- The phytomolecule extended lifespan in the studied model.
- Bakuchiol modulated mRNA expression of genes related to choline transport and ACh synthesis/transport.
- It reduced amyloid β and lipid levels, potentially via upregulation of hsf-1 and autophagy (lgg-1) genes.
Conclusions:
- Bakuchiol is an effective phytomolecule for modulating cholinergic dysfunction.
- It demonstrates neuroprotective properties by enhancing ACh transmission and reducing oxidative stress.
- Bakuchiol's mechanism involves the modulation of key genes in neural transmission, amyloid clearance, and autophagy.
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