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Altered stability of dynamic brain functional architecture in primary open-angle glaucoma: a surface-based
Bingbing Yang1, Mingyue Su1, Qian Wang1
1Department of Radiology, Beijing Tongren Hospital, Capital Medical University, No.1 of Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China.
Brain Imaging and Behavior
|October 19, 2023
Summary
Primary open-angle glaucoma (POAG) patients show reduced brain functional stability, particularly in visual networks. This altered brain connectivity may offer new insights into POAG progression and its neuropathology.
Area of Science:
- Neuroscience
- Ophthalmology
- Medical Imaging
Background:
- Understanding the neuropathology of primary open-angle glaucoma (POAG) is essential for its treatment.
- Temporal stability of brain functional architecture is critical, but its role in POAG is not well understood.
Purpose of the Study:
- To investigate brain functional abnormalities in POAG patients using dynamic functional connectivity (DFC) and functional stability.
- To explore the relationship between functional stability and clinical indicators in POAG.
Main Methods:
- Resting-state functional magnetic resonance imaging (rs-fMRI) was performed on 70 POAG patients and 45 healthy controls.
- DFC stability was calculated using a sliding-window approach, comparing patients and controls.
- Spearman's correlation analysis examined links between functional stability and clinical measures.
Main Results:
- POAG patients exhibited significantly decreased functional stability in visual networks (early visual cortex, ventral/dorsal streams) compared to controls.
- Increased functional stability was observed in the bilateral inferior parietal gyrus and right inferior frontal cortex in POAG patients.
- Dynamic stability in the left early visual and ventral stream visual cortex correlated with visual field defect severity.
Conclusions:
- Functional stability is altered in POAG, with reduced stability in visual processing areas.
- These findings suggest functional stability may be a novel biomarker for understanding brain alterations in POAG progression.
Keywords:
Dynamic functional connectivityFunctional stabilityPrimary open-angle glaucomaResting-state functional magnetic resonance imaging
