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Anti-obesity effect of Neoagaro-oligosaccharides with overweight and obese subjects: a 16-week, randomized,

Hyang-Im Baek1,2, Ki-Chan Ha2, Yu Kyung Park2

  • 1Department of Food Science & Nutrition, Woosuk University, Wanju, 55338, Republic of Korea.

BMC Complementary Medicine and Therapies
|October 19, 2023
PubMed
Abstract

Insights

Neoagaro-oligosaccharides (NAOs) significantly reduced visceral fat and suppressed weight gain in overweight individuals. This study suggests NAOs are a safe and effective anti-obesity supplement without adverse effects.

Area of Science:

  • Nutrition Science
  • Human Physiology
  • Clinical Research

Background:

  • Obesity is a growing global health concern requiring effective interventions.
  • Neoagaro-oligosaccharides (NAOs) are novel compounds with potential anti-obesity properties.
  • A randomized, double-blind, placebo-controlled trial was conducted to assess NAO efficacy and safety.

Purpose of the Study:

  • To evaluate the anti-obesity effects of Neoagaro-oligosaccharides (NAOs) in overweight or obese humans.
  • To assess the safety profile of NAOs during a 16-week intervention period.
  • To determine the impact of NAOs on key metabolic and body composition markers.

Main Methods:

  • 100 overweight/obese participants (BMI 23–34.9 kg/m², body fat >25% males/>30% females) were enrolled.
  • Participants received either 3g of NAOs twice daily or a placebo for 16 weeks.
  • Efficacy and safety biomarkers, including body composition and blood lipids, were measured pre- and post-intervention.

Main Results:

  • NAOs significantly decreased visceral fat area and the visceral-to-subcutaneous fat ratio compared to placebo.
  • The NAO group showed suppressed weight and BMI increases, with significant between-group differences.
  • High-density lipoprotein-cholesterol increased in the NAO group, with a significant trend observed.
  • No adverse clinical changes were noted in safety biomarkers for the NAO group.

Conclusions:

  • NAOs demonstrate a beneficial effect in combating obesity.
  • NAOs can be considered a safe and effective supplement for weight management.
  • Further research may explore long-term effects and optimal dosing of NAOs.
Keywords:
Body weightClinical trialNeoagaro-oligosaccharidesObesityOverweightVisceral fat

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