Related Experiment Video
Updated: Jul 12, 2025
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
Changes in coagulation markers in children with Mycoplasma pneumoniae pneumonia and their predictive value for
Yong-Tao Li1, Ju Zhang2, Meng-Zhu Wang2
1Department of Pediatrics, Luoyang Maternal and Child Health Hospital, No. 206 of Tongqu Road, 471000, Luoyang, Henan province, China.
Background:
This study investigates the correlation between coagulation levels and the severity of Mycoplasma pneumoniae pneumonia (MPP) in children. In addition, the study analyses the predictive value of coagulation abnormalities in MPP combined with necrotising pneumonia (NP).
Methods:
A total of 170 children with MPP who underwent treatment between June 2021 and February 2022 were selected for this study. The study population was divided into groups according to the severity of the disease to compare differences in the incidence of coagulation abnormalities between the groups. The participants were also divided into groups according to imaging manifestations to compare the differences in coagulation function among the different groups. All data information was processed for statistical analysis using SPSS Statistics 25.0 and GraphPad Prism 7.0 statistical analysis software.
Results:
The incidence of coagulation abnormalities in the children in the severe MPP (SMPP) group was significantly higher than that in the normal MPP (NMPP) group (P < 0.05). The multi-factor logistic regression analysis revealed that the D-dimer level is an independent risk factor for the development of NP in SMPP (P < 0.05). The receiver operating characteristic curve analysis revealed statistically significant differences (P < 0.05) in D-dimer, fibrinogen degeneration products (FDP), neutrophils, lactate dehydrogenase and serum ferritin for predicting SMPP combined with NP. Bronchoscopic manifestations of coagulation indicators (D-dimer and FDP levels) were significantly higher in the mucus plug group than in the non-mucus plug group, while the activated partial thromboplastin time levels were lower in the former than in the latter (P < 0.05).
Conclusion:
The degree of elevated D-dimer and FDP levels was positively correlated with the severity of MPP, with elevated serum D-dimer levels (> 3.705 mg/L) serving as an independent predictor of MPP combined with NP in children.
Insights
Elevated D-dimer and fibrinogen degeneration products indicate severe Mycoplasma pneumoniae pneumonia (MPP) in children. High D-dimer levels predict the development of necrotising pneumonia (NP) in children with MPP.
Area of Science:
- Pediatric Infectious Diseases
- Hematology
- Pulmonology
Background:
- Mycoplasma pneumoniae pneumonia (MPP) can lead to severe complications.
- Coagulation abnormalities are increasingly recognized in pediatric respiratory infections.
- The link between coagulation status and disease severity in MPP, particularly with necrotising pneumonia (NP), requires further investigation.
Purpose of the Study:
- To investigate the correlation between coagulation levels and the severity of MPP in children.
- To analyze the predictive value of coagulation abnormalities for MPP combined with NP.
Main Methods:
- Retrospective analysis of 170 children with MPP treated between June 2021 and February 2022.
- Stratification of patients based on disease severity and imaging manifestations.
- Statistical analysis using SPSS and GraphPad Prism.
Main Results:
- Children with severe MPP exhibited a significantly higher incidence of coagulation abnormalities compared to those with normal MPP.
- Elevated D-dimer levels were identified as an independent risk factor for NP in severe MPP.
- D-dimer, FDP, neutrophils, lactate dehydrogenase, and serum ferritin showed predictive value for severe MPP combined with NP.
Conclusions:
- Elevated D-dimer and FDP levels correlate positively with MPP severity.
- Serum D-dimer levels above 3.705 mg/L independently predict MPP combined with NP in children.
More Related Videos
06:04Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
Published on: February 24, 2023
07:43A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice
Published on: September 28, 2016
