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Updated: Jul 12, 2025

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
The risk of muscle involvement in focal venous malformations in children
Jie Zhou1, Lei Guo1, Liang Wang1
1Department of Vascular anomalies and Interventional Radiology, Children's Hospital Affiliated to Shandong University, Jinan, China.
Background:
Venous malformations (VMs) are the most common vascular malformations, which can be classified as focal, multifocal, or diffuse types. But the risk of focal venous malformations with muscle involvement is not well defined.
Methods:
This is a single-center, retrospective review of patients treated for focal VMs between February 2021 and February 2022.
Results:
We assessed 26 patients focal VMs with 47 lesions; 18 (69%) were unifocal, 3 (12%) were dual-focal, and 5 (19%) were multifocal type VMs, and 29 (62%) were intramuscular VMs. The lower limbs intramuscular VMs had a significantly elevated risk of focal VMs (relative risk [RR],1.7; 95% confidence interval [CI], 1.148-2.394).
Conclusion:
Intramuscular involvement of the body should be considered in focal VMs. The lower limbs intramuscular VMs had a significantly elevated risk of focal VMs.
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