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Prolactin Level Changes according to Atypical Antipsychotics Use: A Study Based on Clinical Data Warehouse
Suhyung Kim1,2, Jong-Hyun Jeong1,2, Yoo Hyun Um1,2
1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Summary
Antipsychotic drugs like risperidone and amisulpride significantly increase serum prolactin levels, especially in women. Regular monitoring of prolactin is crucial for patients on antipsychotics.
Area of Science:
- Pharmacology
- Endocrinology
- Psychiatry
Background:
- Antipsychotic medications are a primary cause of non-neoplastic hyperprolactinemia.
- Hyperprolactinemia can lead to various adverse health effects.
Purpose of the Study:
- To investigate serum prolactin levels in patients using different antipsychotic drugs.
- To assess the impact of specific antipsychotics on prolactin levels using real-world clinical data.
Main Methods:
- A cohort of 260 patients diagnosed with schizophrenia, bipolar disorder, or related conditions was identified from the Clinical Data Warehouse (CDW).
- Serum prolactin levels were analyzed in patients taking risperidone, blonanserin, amisulpride, or olanzapine.
- Statistical analyses, including ANCOVA and post hoc tests, were employed to compare prolactin levels across drug groups.
Main Results:
- Among 117 analyzed subjects, mean serum prolactin was 64.6 ± 54.6 ng/ml.
- Risperidone and amisulpride were associated with significantly higher prolactin levels compared to blonanserin and olanzapine.
- Female patients taking blonanserin, olanzapine, and risperidone showed elevated prolactin levels; amisulpride did not show a sex-based difference.
Conclusions:
- Regular monitoring of serum prolactin is recommended for patients on antipsychotics, particularly females.
- The study highlights the utility of the CDW for large-scale health data research.
- Further research with controlled variables and larger cohorts is needed to confirm findings.
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