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Structure-activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-052

Fumihiro Kawagoe1, Sayuri Mototani1, Aileen Mendoza2

  • 1Faculty of Pharmaceutical Sciences, Teikyo University Itabashi-ku Tokyo 173-8605 Japan akittaka@pharm.teikyo-u.ac.jp.

RSC Medicinal Chemistry
|October 20, 2023
PubMed
Summary

New vitamin D analogues inhibit lipid biosynthesis by targeting sterol regulatory element-binding protein (SREBP) and SREBP cleavage-activating protein (SCAP). These compounds lack vitamin D receptor (VDR) activity, offering a potential therapeutic strategy for metabolic disorders.

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