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Related Concept Videos

Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

410
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
410

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Relationship between cognitive function affecting motor Functional Independence Measure and hypnotics.

Hiroko Otsubo1,2, Keiko Kishimoto1, Iyori Hirano3

  • 1Division of Social Pharmacy and Pharmacy Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan.

Japanese Journal of Comprehensive Rehabilitation Science
|October 20, 2023
PubMed
Summary

Hypnotics may improve motor function in older adults with cognitive dysfunction. Specifically, non-benzodiazepine and benzodiazepine hypnotics positively impacted motor Functional Independence Measure efficiency and effectiveness in this patient group.

Keywords:
cognitive functionconvalescent rehabilitation wardhypnoticsmotor FIM

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Area of Science:

  • Gerontology
  • Rehabilitation Medicine
  • Pharmacology

Background:

  • Cognitive dysfunction is a significant concern in elderly patients undergoing rehabilitation.
  • The impact of psychotropic medications, particularly hypnotics, on motor function recovery in this population requires further investigation.

Purpose of the Study:

  • To investigate the relationship between hypnotic use and motor recovery in elderly patients with cognitive dysfunction.
  • To determine if specific classes of hypnotics differentially affect motor outcomes.

Main Methods:

  • A retrospective study analyzed data from 509 patients aged 65 years and older discharged from a rehabilitation ward.
  • Multiple regression analysis assessed the association between hypnotic use (classified by mechanism) and motor Functional Independence Measure (FIM) efficiency and effectiveness (FIM-e) in patients with and without cognitive dysfunction.

Main Results:

  • Hypnotic use was positively associated with improved motor FIM efficiency and FIM-e in patients with cognitive dysfunction.
  • Non-benzodiazepine (non-BZ) hypnotics showed a positive relationship with motor FIM efficiency.
  • Both non-BZ and benzodiazepine (BZ) hypnotics were positively related to motor FIM-e, while hypnotics with new mechanisms did not show significant associations.

Conclusions:

  • The findings suggest that hypnotics can enhance motor recovery in elderly patients experiencing cognitive dysfunction.
  • Specific hypnotic classes, namely non-BZ and BZ hypnotics, appear to be beneficial for improving motor function outcomes in this vulnerable population.