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Rates Among Hospitalized Patients With COVID-19 Treated With Convalescent Plasma: A Systematic Review and

Jonathon W Senefeld^1,2, Ellen K Gorman¹, Patrick W Johnson³

¹Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.

Mayo Clinic Proceedings. Innovations, Quality & Outcomes

|October 20, 2023

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COVID-19 convalescent plasma transfusion reduced mortality in hospitalized patients. High antibody levels and earlier treatment further decreased death risk, showing a significant benefit.

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A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

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Published on: April 28, 2016

Area of Science:

Infectious Diseases
Hematology
Critical Care Medicine

Background:

Hospitalized patients with COVID-19 face significant mortality risks.
COVID-19 convalescent plasma (CCP) is explored as a therapeutic option.

Purpose of the Study:

To evaluate the association between CCP transfusion and mortality in hospitalized COVID-19 patients.
To identify subgroup differences in treatment outcomes.

Main Methods:

Systematic search of clinical studies (Jan 2020-Oct 2022) including randomized trials and matched cohort studies.
Meta-analysis of 39 RCTs (21,529 participants) and 70 cohort studies (50,160 participants).
Data pooled using inverse-variance random effects model, focusing on all-cause mortality.

Main Results:

CCP transfusion was associated with reduced mortality in both RCTs (OR 0.87) and cohort studies (OR 0.76).
High antibody level CCP significantly decreased mortality compared to low antibody level CCP (OR 0.85).
Earlier CCP treatment showed a greater mortality reduction than later treatment (OR 0.63).

Conclusions:

CCP transfusion offers a mortality benefit for hospitalized COVID-19 patients.
Treatment efficacy is enhanced with high-titer CCP and earlier administration.