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Updated: Jul 12, 2025

Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method

Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method

Published on: October 27, 2020

Ocular rigidity and choroidal thickness changes in response to microgravity: A case study.

Marissé Masís Solano^1,2, Charles Bélanger Nzakimuena², Rémy Dumas³

¹Département d'Ophtalmologie, Université de Montréal, Canada.

American Journal of Ophthalmology Case Reports

|October 20, 2023

Summary

This summary is machine-generated.

Spaceflight decreased ocular rigidity and increased choroidal thickness, especially during the Valsalva maneuver. These findings are crucial for understanding spaceflight-associated neuro-ocular syndrome.

Keywords:

Choroidal thickness Microgravity Ocular rigidity Space flight Valsalva

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Area of Science:

Ophthalmology
Space Medicine
Biophysics

Background:

Spaceflight poses risks to astronaut health, including potential ocular changes.
Understanding ocular biomechanics in microgravity is vital for astronaut safety and mission success.

Purpose of the Study:

To assess changes in ocular rigidity and choroidal thickness.
To investigate the effects of microgravity and the Valsalva maneuver on ocular parameters in a private astronaut.

Main Methods:

Ophthalmological examinations and Optical Coherence Tomography (OCT) were conducted pre-, during, and post-spaceflight.
Choroidal thickness was measured at rest and during the Valsalva maneuver.
Ocular rigidity was assessed using a non-invasive method with deep learning-based choroid segmentation.

Main Results:

Ocular rigidity was reduced after spaceflight compared to baseline measurements.
Choroidal thickness increased during the Valsalva maneuver compared to resting states, both in space and on Earth.
The increase in choroidal thickness during the Valsalva maneuver was more pronounced during spaceflight.

Conclusions:

Spaceflight induces biomechanical alterations in ocular tissues.
The observed changes, particularly the enhanced choroidal response to the Valsalva maneuver, may inform the study of spaceflight-associated neuro-ocular syndrome.
Findings have implications for the safety of short-duration missions in the growing commercial space industry.