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Updated: Jul 12, 2025

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
Published on: May 13, 2019
Right Ventricle and Autoimmune Diseases.
Luis Francisco Valdés Corona1, Tatiana Sofía Rodríguez Reyna2
1Department of Rheumatology, Hospital Angeles Lomas, Huixquilucan, Estado de México.
Systemic sclerosis can cause right ventricle damage through inflammation and fibrosis, impacting cardiovascular health. Understanding these changes is crucial for managing this autoimmune disease and its complications.
Area of Science:
- Cardiology
- Rheumatology
- Pathophysiology
Background:
- Autoimmune diseases like systemic sclerosis can cause systemic inflammation and cardiovascular issues.
- Right ventricular dysfunction is observed in several autoimmune conditions, contributing to increased cardiovascular risk.
- Pulmonary arterial hypertension is a significant cause of mortality in systemic sclerosis patients.
Conclusions:
- Right heart alterations in systemic sclerosis require careful distinction based on the presence of pulmonary arterial hypertension.
- Microvascular damage and myocardial fibrosis are key factors in non-pulmonary arterial hypertension-related RV changes.
- Further research is needed to fully elucidate the mechanisms and management of right ventricular dysfunction in systemic sclerosis.
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