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Personality Affects Zebrafish Response to Sertraline.

Asma Al Shuraiqi1, Raeid M M Abed1, Aziz Al-Habsi1

  • 1Biology Department, Sultan Qaboos University, Muscat, Oman.

Environmental Toxicology and Chemistry
|October 20, 2023
PubMed
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Sertraline exposure alters fish behavior, impacting sociability and anxiety, with effects varying by individual personality. Understanding initial behavior is key to predicting responses to this common antidepressant pollutant.

Keywords:
Behavioral toxicologyEcotoxicologyEmerging pollutants

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Area of Science:

  • Environmental Toxicology
  • Behavioral Pharmacology
  • Ecotoxicology

Background:

  • Sertraline, a selective serotonin reuptake inhibitor (SSRI), is frequently detected in aquatic environments.
  • Antidepressants in surface waters pose risks to aquatic organisms, potentially altering behavior.

Purpose of the Study:

  • To investigate the impact of sertraline on zebrafish behavior across different personality types.
  • To assess behavioral changes in boldness, anxiety, and sociability following sertraline exposure.
  • To explore the relationship between gut microbiome, personality, and pollutant response.

Main Methods:

  • Zebrafish were categorized by personality (boldness, anxiety, sociability) and exposed to varying sertraline concentrations (0-5000 ng/L) for 7 and 28 days.
  • Behavioral assays included sociability tests, anxiety responses, and alarm cue reactivity.
  • Gut microbiome analysis was performed on a subset of fish.

Main Results:

  • Sertraline exposure reduced sociability in all treatment groups, with greater impact on fish with low initial sociability.
  • Higher sertraline concentrations (2200 ng/L) increased anxiety after 7 days.
  • Behavioral responses were influenced by initial personality and sex, particularly in females with low boldness.

Conclusions:

  • Initial personality traits significantly modulate behavioral responses to sertraline in zebrafish.
  • Environmental concentrations of sertraline can alter fish behavior, highlighting ecological risks.
  • Findings suggest individual variability in drug response may be linked to baseline behavior, with implications for both wildlife and human pharmacology.