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A Simplified Technique for Producing an Ischemic Wound Model
Published on: May 2, 2012
Retrospective Data Analysis of the Use of an Autologous Multilayered Leukocyte, Platelet, and Fibrin Patch for
Jason M Mendivil1, Lorena C Henderson, Orion S Olivas
1At PULSE Amputation Prevention Centers, El Paso, Texas, USA, Jason M. Mendivil, DPM, is Medical Director; and Lorena C. Henderson, APRN, MSN, FNP-C, is Clinical Research Coordinator. Orion S. Olivas is Pre-medical Student, Houston Christian University, Texas. Mia A. Deanda is Undergraduate Student, University of Texas at El Paso. Martin L. Johnson, MD, MPH, FACS, is Plastic Surgeon, Casa Colina Hospital and Centers for Healthcare, Casa Colina Hyperbaric Medicine & Wound Care Center, Casa Colina, California. The authors have disclosed no financial relationships related to this article. Submitted January 6, 2023; accepted in revised form March 24, 2023.
Objective:
To describe the healing outcome of chronic, hard-to-heal diabetic foot ulcers (DFUs) treated with an autologous multilayered leukocyte, platelet, and fibrin (MLPF) patch in addition to the best standard of care, in a real-world clinical setting of two US amputation preventive centers.
Methods:
In this retrospective study of patients treated between September 2021 and October 2022, the authors analyzed DFU healing outcomes based on Wound, Ischemia, and foot Infection-derived amputation risk.
Results:
All 36 patients had a diagnosis of type 2 diabetes and 29 (81%) were male. Their average age was 61.4 years, body mass index was 29.2 kg/m2, and glycated hemoglobin was 7.9. Twenty-seven patients (78%) were diagnosed with peripheral vascular disease, 20 (56%) underwent a peripheral vascular procedure, 15 (42%) had a prior amputation, and 6 (17%) were on hemodialysis. Average wound size was 4.9 cm2, and wound age was 9.5 months. Twelve patients (32%) were classified as low risk, 15 (39%) as moderate risk, and 11 (29%) as high risk for amputation. Within 12 weeks of the first MLPF patch application, nine wounds (24%) healed. After 20 weeks, 23 wounds (61%) were closed, and by follow-up, 30 wounds (79%) healed. No amputations were noted. Compared with published data, 40% fewer patients underwent readmission within 30 days, with 72% shorter admission duration.
Conclusions:
Real-world clinical experiences using the MLPF patch to treat hard-to-heal DFUs resulted in the majority of wounds healing. Few patients experienced a readmission within 30 days, and the average admission duration was short.
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