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Related Experiment Video

Updated: Jul 12, 2025

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Noninvasive Framework Nucleic Acid Eye Drops for Retinal Administration.

Shitai Zhu1,2, Qinglong Yan3, Lihua Wang1,4,2

  • 1Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.

ACS Applied Bio Materials
|October 20, 2023
PubMed
Summary

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This summary is machine-generated.

This study introduces novel DNA nanostructures for noninvasive eye treatments. These framework nucleic acids (FNAs) efficiently deliver drugs to the retina via eye drops, overcoming current injection limitations.

Area of Science:

  • Ophthalmology
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Intravitreal injection is a common method for retinal disease treatment but has significant drawbacks.
  • These include ocular trauma, infection risk, and poor patient compliance due to frequent administrations.
  • Developing effective noninvasive ophthalmic drug delivery to the retina is challenging due to biological barriers like the cornea.

Purpose of the Study:

  • To develop and evaluate size- and shape-resolved fluorescent DNA frameworks for noninvasive retinal drug delivery.
  • To assess the efficiency and biocompatibility of these nanocarriers for retinal administration.

Main Methods:

  • Utilized framework nucleic acids (FNAs) for their biocompatibility and controllable nanostructure properties.
  • Engineered tetrahedral DNA nanostructures (TDNs) with specific dimensions (20 bp edge length).
Keywords:
framework nucleic acids (FNAs)noninvasive ophthalmic eye dropsretinal administrationshapesizetetrahedral DNA nanostructures (TDNs)

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  • Investigated the retinal delivery efficiency and biocompatibility of these TDNs in an ophthalmic context.

    • Main Results:

    • Tetrahedral DNA nanostructures (TDNs) with a 20 bp edge length demonstrated efficient retinal penetration within 6 hours.
    • The developed FNA-based nanocarriers exhibited excellent biocompatibility.
    • Size and shape optimization of FNAs is crucial for efficient noninvasive retinal drug delivery.

    Conclusions:

    • Framework nucleic acids offer a promising platform for noninvasive retinal drug delivery.
    • Optimized DNA nanostructures can overcome ocular barriers to reach the retina effectively.
    • This approach provides a new strategy for localized treatment of retinal diseases, improving patient compliance and safety.