Related Experiment Video

Updated: Jul 12, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

262

Glucose indices as inflammatory markers in children with acute surgical abdomen: a cross-sectional study

Hoda Atef Abdelsattar Ibrahim1, Sherif Kaddah2, Sara Mohamed Elkhateeb3

  • 1Paediatric Clinical Nutrition Unit, Paediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Annals of Medicine
|October 20, 2023
PubMed

Insights

Preoperative high blood sugar and HbA1c levels indicate inflammation in children with acute surgical abdomen. Random blood sugar (RBS) can predict severity, while HbA1c may serve as an inflammatory marker.

Area of Science:

  • Pediatric Surgery
  • Endocrinology
  • Inflammation Research

Background:

  • Glycemic dysregulation exacerbates inflammation and oxidative stress, linking preoperative hyperglycemia to increased mortality.
  • Inflammation correlates with elevated glycated hemoglobin (HbA1c), with a potentially non-linear relationship to random blood sugar (RBS).

Purpose of the Study:

  • To investigate the role of glycemic parameters (HbA1c and RBS) as potential inflammatory markers in pediatric patients with acute surgical abdomen.
  • To assess the correlation between RBS, HbA1c, and inflammatory markers like total leucocytic count (TLC) in this patient group.

Main Methods:

  • A cross-sectional study involving non-diabetic pediatric patients with acute surgical abdomen over six months.
  • Screening of random blood sugar (RBS) and glycated hemoglobin (HbA1c) levels in enrolled patients.

Main Results:

  • High prevalence of glycemic dysregulation (66% abnormal HbA1c, 60% stress hyperglycemia).
  • Significant correlation between RBS and total leucocytic count (TLC) (r=0.770, p<0.001).
  • Elevated RBS in complicated appendicitis compared to uncomplicated cases.

Conclusions:

  • HbA1c and RBS may serve as inflammatory markers for acute surgical abdomen and its severity.
  • RBS can act as a surrogate inflammatory marker, rising with disease progression due to stress hyperglycemia.
Abstract

Keywords:
Acute AbdomenAcute AppendicitisGlycaemic DysregulationGlycated Haemoglobin (HbA1c)Inflammatory MarkersPaediatric Surgical EmergenciesRandom Blood Sugar (RBS)Stress Hyperglycaemia

More Related Videos

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

14.2K
Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo10:35

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

Published on: April 6, 2022

2.8K

Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
131
Glucose Absorption Into the Small Intestine01:26

Glucose Absorption Into the Small Intestine

Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
31.8K
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
22.8K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
274
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
80