Towards a REASSURED reality: A less-is-more electronic design strategy for self-powered glucose test

Sensing strategies adopting minimal electronic systems help in realizing REASSURED diagnostic tests. However, the challenge in developing such strategies escalates with demand in power and electronics during pursuit of reliable and accurate sensing. Herein, we present an electronic design strategy using a smart strip, operating with power generated from 3.5 μL of serum sample, to reveal glucose concentration through a response preserved in a capacitor. Further, by integrating an NFC tag alongside the strip, we devised a self-powered glucose measuring card, mobile-glucocard (or mGlucocard) for retrieving this stored digital response using smartphone, enabling 'connected mobile-health diagnostics'. The response from our device relates linearly to glucose concentration offering a sensitivity of 11.3 mV/mM and good correlation (R = 0.974) with colorimetric reference method. Interestingly, the design strategy uses only four components - two resistors, diode, and capacitor - of simple architecture likely transferable to printed technologies to deliver advanced self-powered sustainable devices.