[Role of the liver in formation of the natriuretic factor]

A response to an increase in the liquid volume and the level of the natriuretic factor in the blood were studied 30 h, 3, 7, 14 and 28 days after removal of 2/3 of the liver mass in rats. The state of the liver was studied in parallel in the same periods. Volumetric natriuresis in rats and the NUF level in the blood after partial hepatectomy decreased sharply and increased gradually by the 28th day, i.e. by the time of liver mass regeneration. The NUF content by that time remained lowered. The results have confirmed earlier reports on NUF formation or activation in the liver.