Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

136
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
136

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted polymeric nanoparticles enable epithelial translocation of PROTACs and preserve intracellular protein degradation activity.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026
Same author

Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology.

Journal of neuroinflammation·2026
Same author

From prototype to veterinary patient: a pharmacokinetic clinical trial of 3D-printed pimobendan tablets in beagle dogs.

Drug delivery and translational research·2026
Same author

N-acetylcysteine mitigates oxidative stress and reduces alveolar bone damage on experimental periodontitis in rats.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same author

Semi-solid Extrusion 3D Printing of Chitosan/Carbon Nanotube Nanocomposite Films for Microextraction of Pesticides in Water.

ACS omega·2026
Same author

Silver phosphate as an antimicrobial and remineralizing agent in orthodontic resins.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics·2026

Related Experiment Video

Updated: Jul 12, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.3K

Poly(ɛ-caprolactone) and Eudragit E blends modulate the drug release profiles from FDM printlets.

Juliana Dos Santos1, Tobias Kielholz2, Nadine Lysyk Funk1

  • 1Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752, Porto Alegre, Rio Grande do Sul 90610-000, Brazil; Laboratório de Nanocarreadores e Impressão 3D em Tecnologia Farmacêutica (Nano3D), Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brasil.

International Journal of Pharmaceutics
|October 20, 2023
PubMed
Summary

Blending Poly(ε-caprolactone) (PCL) with Eudragit E (EudE) enhances drug release from 3D printed dosage forms. Incorporating up to 40% EudE improves drug delivery without compromising printability.

Keywords:
Additive manufacturingGlucocorticoidPersonalized medicinePrintabilityTablets

More Related Videos

Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants
11:32

Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants

Published on: December 23, 2013

11.9K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.9K

Related Experiment Videos

Last Updated: Jul 12, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.3K
Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants
11:32

Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants

Published on: December 23, 2013

11.9K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.9K

Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Polymer Chemistry

Background:

  • Thermoplastic polymers are extruded into filaments for 3D printing, enabling the creation of personalized dosage forms (printlets).
  • Poly(ε-caprolactone) (PCL) offers excellent mechanical and printability properties for 3D printing but exhibits slow drug release due to its hydrophobicity.
  • Enhancing drug release from PCL-based printlets is crucial for effective therapeutic delivery.

Purpose of the Study:

  • To investigate the potential of blending Eudragit E (EudE), a less hydrophobic polymer, with PCL to improve drug release rates from 3D printed dosage forms.
  • To evaluate the impact of varying PCL:EudE ratios on filament properties, printability, and drug release kinetics.
  • To assess the mechanical integrity and component homogeneity of the resulting 3D printlets.

Main Methods:

  • Hot melt extrusion (HME) was used to produce PCL:EudE blend filaments at various weight ratios (50:50, 60:40, 70:30, 80:20) containing 5% dexamethasone.
  • Filament extrudability and printability using fused deposition modelling (FDM) were assessed.
  • The drug release behavior and component distribution within the 3D printedlets were analyzed.

Main Results:

  • Filaments were successfully extruded and printed, except for the 50:50 PCL:EudE blend.
  • Printlets exhibited homogeneous distribution of PCL, EudE, and dexamethasone.
  • Drug release rate increased with higher EudE content, with the 60:40 PCL:EudE ratio showing the fastest release, without compromising mechanical or printing properties.

Conclusions:

  • Blending PCL with EudE is an effective strategy to accelerate drug release from 3D printed dosage forms.
  • The 60:40 PCL:EudE ratio provides an optimal balance for enhanced drug delivery and printability.
  • This approach offers a promising method for tailoring drug release profiles from PCL-based 3D printlets.