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Related Experiment Videos

Tyrosine influence on amphetamine self-administration and brain catecholamines in the rat.

L S Geis, D G Smith, F L Smith

    Pharmacology, Biochemistry, and Behavior
    |November 1, 1986
    PubMed
    Summary

    L-tyrosine administration did not affect amphetamine self-administration in rats with short-term exposure. However, it significantly reduced self-injection in rats with chronic amphetamine exposure, suggesting treatment efficacy depends on drug abuse history.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Addiction Research

    Background:

    • L-tyrosine is a precursor to dopamine (DA) and norepinephrine (NE), neurotransmitters implicated in drug abuse.
    • Previous studies indicated L-tyrosine could modulate DA and NE levels following amphetamine exposure.

    Purpose of the Study:

    • To investigate the behavioral and neurochemical effects of L-tyrosine administration on d-amphetamine self-administration in rats.
    • To determine if the duration of amphetamine exposure influences the efficacy of L-tyrosine as a potential treatment.

    Main Methods:

    • Rats trained to self-administer intravenous d-amphetamine were administered L-tyrosine.
    • Neurochemical analyses were performed to measure changes in DA and NE metabolites.
    • Experiments utilized a computer-controlled apparatus to mimic self-administration patterns.

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    Main Results:

    • In rats with <35 days of amphetamine exposure, L-tyrosine did not alter self-administration behavior.
    • L-tyrosine antagonized amphetamine-induced norepinephrine depletions and increased dopamine metabolite (DOPAC) in the striatum.
    • In rats with 4-6 months of chronic amphetamine exposure, L-tyrosine significantly reduced daily drug self-injection.

    Conclusions:

    • The effectiveness of L-tyrosine in modulating amphetamine self-administration is dependent on the duration of prior drug exposure.
    • Chronic amphetamine abuse may alter neurochemical responses to L-tyrosine, impacting its therapeutic potential.
    • Treatment strategies for psychomotor stimulant abuse may need to consider the subject's history of drug use.