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Lymphomas and Amyloid in the Gastrointestinal Tract
Alisha D Ware1, Laura M Wake2, Yuri Fedoriw3
1Department of Pathology & Laboratory Medicine, University of North Carolina School of Medicine, 160 Medical Drive, Brinkhous-Bullitt Building, CB#7525, Chapel Hill, NC 27599, USA.
Surgical Pathology Clinics
|October 20, 2023
Summary
This review covers lymphoid neoplasms frequently affecting the gastrointestinal tract. It highlights recent classification updates for accurate diagnosis and patient management of these complex lymphomas.
Area of Science:
- Hematology
- Oncology
- Gastroenterology
Background:
- Lymphoproliferative disorders encompass a diverse range of neoplasms with varied characteristics.
- The gastrointestinal tract is a common site for both primary and secondary involvement by lymphomas.
- Accurate differentiation of gastrointestinal lymphoproliferative disorders is crucial for effective patient management.
Purpose of the Study:
- To review lymphoid neoplasms with significant gastrointestinal involvement.
- To provide updates based on recent hematolymphoid neoplasm classification systems.
- To emphasize the importance of distinguishing between different types of gastrointestinal lymphoproliferative disorders.
Main Methods:
- Literature review of lymphoid neoplasms involving the gastrointestinal tract.
- Analysis of recent updates in hematolymphoid neoplasm classification.
- Synthesis of information on clinical, morphologic, immunophenotypic, and genetic features.
Main Results:
- Lymphoid neoplasms exhibit diverse presentations in the gastrointestinal tract.
- Recent classifications refine the understanding and categorization of these disorders.
- Distinguishing indolent lymphoproliferative disorders from aggressive lymphomas is a key challenge.
Conclusions:
- Accurate classification of gastrointestinal lymphoid neoplasms is essential for optimal patient care.
- Understanding recent updates in hematolymphoid neoplasm classification aids in diagnosis.
- Further research is needed to fully elucidate the behavior and treatment of these disorders.
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