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Pediatric thyroid cancer: Socioeconomic disparities and their impact on access to care
Heming H Zhao1, Scott M Wilhelm1
1University Hospitals, Cleveland Medical Center, Cleveland, OH.
Insights
Disparities exist in pediatric thyroid cancer care access and outcomes. Socioeconomic factors and race significantly impact treatment delays and survival for differentiated thyroid cancer patients.
Area of Science:
- Pediatric Oncology
- Health Services Research
- Cancer Disparities
Background:
- Limited research exists on healthcare access disparities for pediatric thyroid cancers.
- Understanding socioeconomic and patient factors influencing care for pediatric differentiated thyroid cancer (DTC) and aggressive papillary thyroid cancer (PTC) variants is crucial.
Purpose of the Study:
- To investigate socioeconomic and patient-related factors affecting access to care for pediatric differentiated thyroid cancer and aggressive papillary thyroid cancer variants.
- To identify trends in access to care and outcomes over time.
- To analyze racial/ethnic and socioeconomic disparities in treatment and survival.
Main Methods:
- Retrospective analysis of the National Cancer Database (2004-2019) for pediatric DTC and aggressive PTC.
- Patients categorized into three time periods (2004-2008, 2009-2013, 2014-2019) to assess temporal trends.
- Statistical analyses (chi-squared, Kruskal-Wallis) used to evaluate socioeconomic and disease factors.
Main Results:
- Analysis included 6,275 pediatric DTC patients and 182 with aggressive PTC.
- Medicaid and lower-income DTC patients faced longer travel distances for care (2014-2019).
- Racial/ethnic disparities observed: Black and Hispanic patients had higher odds of delayed surgery (>30 days). Black DTC patients showed increased mortality risk compared to White and Hispanic patients. Nodal positivity was higher in Hispanic DTC patients.
- Socioeconomic factors did not significantly impact survival or nodal positivity in aggressive PTC variants.
Conclusions:
- Significant disparities in access to care and survival outcomes exist for pediatric DTC and aggressive PTC.
- Race, income, and insurance type are key determinants of these disparities.
- Further research and targeted interventions are necessary to improve care access and patient outcomes.
Background:
Few studies have examined the disparities in access to care for pediatric thyroid cancers. We sought to clarify socioeconomic and patient factors that affect access to care for pediatric differentiated thyroid cancer and aggressive variants of papillary thyroid cancer.
Methods:
Using the National Cancer Database, we performed a retrospective study on pediatric differentiated thyroid cancer and aggressive variants of papillary thyroid cancer (2004-2019). Patients were divided into three periods (2004-2008, 2009-2013, 2014-2019) to assess for trends. The χ2 analysis and Kruskal-Wallis test were used to test for independence of groupings for each socioeconomic and disease-related factor.
Results:
In all, 6,275 patients with pediatric differentiated thyroid cancer and 182 with aggressive variants of papillary thyroid cancer were analyzed. Differentiated thyroid cancer patients with Medicaid (median 18.0 miles) and those from lower-income households (median 21-30 miles) had to travel greater distances for care in recent years (2014-2019). Racial/ethnic disparities were evident; Black and Hispanic patients have higher odds of waiting >30 days for surgery (odds ratio 1.39, 1.49, P < .05, respectively) than White patients. Black patients with differentiated thyroid cancer had a higher risk of mortality compared with White and Hispanic patients (hazard ratio 4.31, 95% confidence interval: 1.95-9.51, P < .05). Nodal positivity was higher in Hispanic patients with differentiated thyroid cancer (60%, P < .05, White patients 51% and Black patients 36%). Socioeconomic factors did not significantly affect survival or nodal positivity in aggressive variants of papillary thyroid cancer.
Conclusion:
This study highlights disparities in access to care and survival outcomes in pediatric differentiated thyroid cancer and aggressive variants of papillary thyroid cancer. Race, income status, and type of insurance all play a role in these disparities. Understanding the complex etiologies and developing interventions to improve access and patient outcomes are crucial.
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