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Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
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Recovery kinetics following eccentric exercise is volume-dependent.

Anastasia Rosvoglou1, Ioannis G Fatouros1, Athanasios Poulios1

  • 1Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.

Journal of Sports Sciences
|October 21, 2023
PubMed
Summary

Eccentric exercise volume significantly impacts muscle damage and recovery. Higher volumes (150 and 300 contractions) caused greater performance loss and delayed recovery compared to lower volumes (75 contractions).

Keywords:
Eccentric exerciseinflammatory responsemuscle damageperformancerecovery kinetics

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Area of Science:

  • Exercise Physiology
  • Sports Science
  • Muscle Biology

Background:

  • Eccentric contractions are known to induce muscle damage.
  • The dose-response relationship between eccentric exercise volume and recovery kinetics is not fully understood.
  • Understanding these effects is crucial for optimizing training and rehabilitation protocols.

Purpose of the Study:

  • To compare the effects of different volumes of intensity-matched eccentric contractions (75, 150, and 300) on muscle damage.
  • To investigate the impact of these volumes on performance recovery kinetics.
  • To analyze inflammatory and oxidative stress markers in response to varying eccentric exercise volumes.

Main Methods:

  • Ten healthy males participated in a randomized, cross-over study with four trials: 75, 150, 300 eccentric contractions (ECC75, ECC150, ECC300), and a control.
  • A 4-week washout period was implemented between trials.
  • Muscle damage, performance (peak torque, jump indices), inflammatory markers, and oxidative stress markers were assessed at multiple time points.

Main Results:

  • Peak torque decreased significantly in ECC150 and ECC300 groups within 48 hours, while ECC75 showed no significant changes.
  • Countermovement jump performance was impaired post-exercise and at 24 hours for ECC150 and ECC300, with ECC300 showing a greater reduction.
  • Muscle soreness, creatine kinase levels, and markers of oxidative stress (protein carbonyls) increased, while glutathione decreased, in a volume-dependent manner, particularly evident up to 192 hours in the ECC300 group.

Conclusions:

  • Muscle damage and performance recovery following eccentric exercise are significantly influenced by exercise volume.
  • Higher volumes of eccentric contractions lead to more pronounced muscle damage and slower recovery kinetics.
  • These findings suggest that training and rehabilitation programs should carefully consider the volume of eccentric exercise to manage muscle damage and optimize recovery.