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Programmable Biomolecule-Mediated Processors
Jian-Jun Shu1, Zi Hian Tan1, Qi-Wen Wang1
1School of Mechanical & Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798.
Journal of the American Chemical Society
|October 21, 2023
Summary
Programmable biomolecule-mediated computing offers a novel approach to computation using biological molecules. This perspective explores conceptual designs for these processors, highlighting future research avenues in this emerging field.
Area of Science:
- Biomolecular Computing
- Molecular Information Processing
- Computational Biology
Background:
- Contemporary computing relies on electronic principles.
- Programmable biomolecule-mediated computing utilizes nucleic acids and analogous structures for information storage and processing.
- This field presents a new paradigm with significant potential.
Purpose of the Study:
- To investigate key issues surrounding programmable biomolecule-mediated processors.
- To present conceptual designs for processors capable of automatic information processing, storage, and display.
- To offer insights into future research directions for biomolecular computing.
Main Methods:
- Conceptual design of programmable biomolecule-mediated processors.
- Exploration of information storage and processing using biomolecular substrates.
- Analysis of requirements for automatic information handling.
Main Results:
- Several conceptual designs for programmable biomolecule-mediated processors are proposed.
- The potential for automatic information processing, storage, and display using biomolecules is discussed.
- Key challenges and opportunities in the field are identified.
Conclusions:
- Programmable biomolecule-mediated computing represents a significant advancement over traditional electronic computing.
- Further research into conceptual designs and future directions is crucial for advancing this field.
- Biomolecular processors hold promise for novel computational capabilities.

