Mechanisms of landiolol-mediated positive inotropy in critical care settings

To present the potential mechanisms by which landiolol enhances a positive inotropic response in critically ill patients.

Analysis of preclinical, animal, and clinical data to provide novel knowledge and translate research findings into potential clinical application.

The super-selective β1-antagonist landiolol may increase inotropy and may be associated with positive outcomes in critically ill patients with acute decompensated heart failure or sepsis.

This review sheds light on the potential mechanisms by which landiolol enhances a positive inotropic response, potentially alleviating the long-held concern over possible negative hemodynamic effects in critically ill patients.