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Updated: Jul 12, 2025
Generation of Human Kidney Tubuloids from Tissue and Urine
Published on: April 16, 2021
Advancements in kidney organoids and tubuloids to study (dys)function
E Dilmen1, I Orhon1, J Jansen2
1Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Abstract:
The rising prevalence of kidney diseases urges the need for novel therapies. Kidney organoids and tubuloids are advanced in vitro models and have recently been described as promising tools to study kidney (patho)physiology. Recent developments have shown their application in disease modeling, drug screening, and nephrotoxicity. These applications rely on their ability to mimic (dys)function in vitro including endocrine activity and drug, electrolyte, and water transport. This review provides an overview of these emerging kidney models and focuses on the most recent developments that utilize their functional capabilities. In addition, we cover current limitations and provide future perspectives for this rapidly evolving field, including what these functional properties mean for translational and personalized medicine now and in the future.
Insights
Novel kidney organoids and tubuloids offer advanced in vitro models for studying kidney disease and drug effects. These functional models show promise for personalized medicine and developing new kidney therapies.
Area of Science:
- Nephrology
- Regenerative Medicine
- Biotechnology
Background:
- Kidney diseases are increasing, necessitating new therapeutic strategies.
- Kidney organoids and tubuloids are sophisticated in vitro models that mimic kidney (patho)physiology.
- These models are emerging as valuable tools for disease modeling, drug screening, and assessing nephrotoxicity.
Purpose of the Study:
- To review recent advancements in functional kidney organoid and tubuloid models.
- To highlight their applications in mimicking kidney (dys)function, including transport and endocrine activity.
- To discuss current limitations and future perspectives for translational and personalized kidney medicine.
Main Methods:
- Literature review of recent developments in kidney organoid and tubuloid research.
- Focus on studies demonstrating functional mimicry of kidney physiology and pathophysiology.
- Analysis of applications in disease modeling, drug screening, and nephrotoxicity assessment.
Main Results:
- Kidney organoids and tubuloids can replicate key kidney functions in vitro, such as endocrine activity and transport processes.
- These models have demonstrated utility in disease modeling and drug testing.
- Recent developments focus on enhancing the functional complexity and physiological relevance of these models.
Conclusions:
- Functional kidney organoids and tubuloids represent a significant advancement in in vitro kidney research.
- Their ability to mimic kidney (dys)function holds great potential for accelerating the development of novel kidney therapies.
- Further development is crucial for realizing their full potential in translational and personalized medicine.
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