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Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
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Acute kidney injury after cardiac surgery

Thilo von Groote1, Mahan Sadjadi, Alexander Zarbock

  • 1Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

Current Opinion in Anaesthesiology
|October 22, 2023
PubMed

Insights

Cardiac surgery-associated acute kidney injury (CS-AKI) poses significant risks. Novel biomarker-guided strategies and precision medicine offer new hope for preventing and managing CS-AKI in high-risk patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Critical Care Medicine

Background:

  • Cardiac surgery patients face a high risk of developing cardiac surgery-associated acute kidney injury (CS-AKI).
  • CS-AKI is linked to adverse outcomes, including persistent renal dysfunction, increased morbidity, and mortality.
  • Understanding the epidemiology and pathophysiology of CS-AKI is crucial for effective management.

Conclusions:

  • Precision medicine approaches are essential for preventing AKI in cardiac surgery patients.
  • Early detection through novel biomarkers is key.
  • Implementing tailored strategies can mitigate the risk of CS-AKI.
Abstract

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