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Nrf2: A promising therapeutic target in bone-related diseases

Jingmin Che1, Xiaoli Yang1, Zhankui Jin2

  • 1Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China; Shaanxi Engineering Research Center of Cell Immunology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|October 22, 2023
PubMed

Insights

Nuclear factor erythroid-2-related factor 2 (Nrf2) protects cells from damage by regulating antioxidant genes. Targeting Nrf2 with natural compounds may offer new treatments for bone diseases caused by oxidative stress.

Area of Science:

  • Cellular Biology
  • Biochemistry
  • Pathology

Background:

  • Oxidative stress and REDOX imbalance are implicated in bone-related diseases.
  • Nuclear factor erythroid-2-related factor 2 (Nrf2) is a key regulator of cellular defense mechanisms against oxidative stress.

Purpose of the Study:

  • To review the biological characteristics of Nrf2.
  • To explore the role of Nrf2-regulated REDOX imbalance in bone diseases.
  • To elucidate the therapeutic potential of natural products targeting Nrf2 for bone conditions.

Main Methods:

  • Literature review of Nrf2 function and its involvement in bone pathophysiology.
  • Analysis of studies on natural extracts targeting Nrf2 pathways.
  • Synthesis of current understanding of Nrf2's impact on bone remodeling and disease.

Main Results:

  • Nrf2 activation promotes antioxidant gene expression, mitigating bone remodeling imbalance.
  • Nrf2 plays a role in fracture recovery, osteoarthritis prevention, and tumor resistance in bone.
  • Natural extracts targeting Nrf2 show promise for treating osteogenic arthropathy.

Conclusions:

  • Nrf2 is a critical mediator in cellular homeostasis and bone health.
  • Understanding Nrf2's role in REDOX imbalance offers insights into bone disease mechanisms.
  • Targeting Nrf2 with natural products presents a promising therapeutic strategy for bone-related diseases.
Keywords:
FactureNrf2OsteoarthritisOsteoporosisOxidativeTherapeutic target

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