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Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue NALT in Mouse Responses to Vaccines
Published on: August 1, 2012
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Lessons learned after 20 years of real-world experience with natalizumab
Bhupendra O Khatri1, Tayo Olapo1, Sara Beals1
1The Regional MS Center, Center for Neurological Disorders SC, Ascension St. Francis Hospital, 3237 S. 16th Street, Milwaukee, WI 53215, United States.
Multiple Sclerosis and Related Disorders
|October 22, 2023
Summary
Natalizumab (NTZ) is effective for multiple sclerosis (MS) but carries a risk of progressive multifocal leukoencephalopathy (PML). This study found no PML cases in a large cohort, suggesting careful monitoring and extended interval dosing may reduce risk.
Area of Science:
- Neurology
- Immunology
Background:
- Natalizumab (NTZ) is a crucial therapy for multiple sclerosis (MS).
- NTZ treatment is associated with an increased risk of progressive multifocal leukoencephalopathy (PML).
- A 20-year experience with NTZ at a single center revealed no PML cases.
Approach:
- Retrospective review of 766 patients treated with NTZ from 2006 to 2020.
- Evaluation of patient characteristics, treatment practices, and clinical/MRI findings.
- Comparison of observed PML incidence to global and US rates and published risk estimates.
Key Points:
- No cases of PML were observed in 766 patients receiving NTZ.
- Regular neurological examinations and potential therapy pauses were implemented.
- Extended interval dosing (EID) was used in 31% of patients without increasing radiological disease worsening compared to standard interval dosing (SID).
Conclusions:
- Careful clinical monitoring and the use of EID may mitigate the risk of PML in MS patients on NTZ.
- These strategies may allow for continued NTZ efficacy while enhancing patient safety.
Keywords:
Extended interval dosingMultiple sclerosisNatalizumabProgressive multifocal leukoencephalopathyReal-world evidenceMore Related Videos
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