Related Experiment Video
Updated: Jul 12, 2025
An Orthotopic Glioblastoma Mouse Model Maintaining Brain Parenchymal Physical Constraints and Suitable for Intravital Two-photon Microscopy
Published on: April 21, 2014
Encephalic meningioangiomatosis in a dog with high-grade undefined glioma
Brenda O Silveira1, Stella M P de Melo1, Fernanda G Cony1
1Setor de Patologia Veterinária, Departamento de Patologia Clínica Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9090, Prédio 42505, Porto Alegre, RS 91540-000, Brazil; Programa de Pós-Graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9090, Porto Alegre, RS 91540-000, Brazil.
Abstract:
Meningioangiomatosis (MA) is a rare proliferative meningovascular disorder that affects mainly the cerebral cortex, brainstem and spinal cord of humans and animals and can coexist with other proliferative disorders. A 7.5-year-old male Brazilian Campeiro Bulldog died after a convulsive crisis and cardiorespiratory arrest. At necropsy, a firm, white mass involving the piriform and right occipital lobes was seen. Histologically, the mass consisted of two morphologically distinct entities that collided: a congenital malformation characterized by a proliferation of meningothelial cells around blood vessels, within the perivascular spaces; and a neoplasm composed of two cell populations with astrocytic and oligodendrocytic differentiation. Meningothelial cells and neoplastic glial cells immunolabelled for vimentin. This first reported case of encephalic MA with a high-grade undefined glioma in a dog was confirmed through clinical signs, pathological and immunohistochemical findings.
Insights
Meningioangiomatosis (MA) is a rare disorder affecting the brain. This study details a unique case in a dog, revealing a collision between MA and a high-grade glioma.
Area of Science:
- Veterinary Pathology
- Neuroscience
- Oncology
Background:
- Meningioangiomatosis (MA) is a rare meningovascular disorder affecting the central nervous system in humans and animals.
- MA can coexist with other proliferative disorders, complicating diagnosis and treatment.
Observation:
- A 7.5-year-old Brazilian Campeiro Bulldog presented with seizures and cardiorespiratory arrest.
- Necropsy revealed a white mass in the cerebral cortex, histologically showing a collision between MA and a high-grade glioma with astrocytic and oligodendrocytic differentiation.
Findings:
- Immunohistochemistry confirmed vimentin expression in both meningothelial and neoplastic glial cells.
- This is the first reported case of canine encephalic MA coexisting with a high-grade undefined glioma.
Implications:
- This case expands the understanding of MA's potential coexistence with other central nervous system neoplasms.
- Highlights the importance of comprehensive pathological and immunohistochemical evaluation in complex neurological cases in veterinary medicine.
