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Related Experiment Video

Updated: Jul 12, 2025

Inducing Apical Periodontitis in Mice

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Systemic Type 2 Inflammation-Associated Atopic Dermatitis Exacerbates Periodontitis.

Yuan Liu^1,2, Ziyuan Wang³, Wenting Jiang⁴

¹Central Laboratory, Peking University School of Stomatology, Beijing, China, liuyuan_0528@sina.com.

International Archives of Allergy and Immunology

|October 22, 2023

Summary

Atopic dermatitis (AD) exacerbates periodontitis by promoting type 2 inflammation and altering oral microbiota. This study reveals cellular and microbial shifts during this progression.

Keywords:

Atopic dermatitis Oral microbiota Periodontitis Th2A cells Type 2 inflammation

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Published on: January 21, 2020

Area of Science:

Immunology
Microbiology
Oral Health

Background:

Atopic dermatitis (AD) is a chronic inflammatory skin disease driven by type 2 inflammation.
AD is linked to an increased incidence of oral disorders, including periodontitis.
Mechanistic insights into how AD impacts periodontitis are needed.

Purpose of the Study:

To investigate the mechanistic link between atopic dermatitis and periodontitis.
To understand how AD influences inflammation and bone resorption in the gingiva.
To explore cellular and microbial changes during AD-periodontitis progression.

Main Methods:

Atopic dermatitis (AD) and periodontitis (P) were induced in a mouse model.
Histomorphology and cytology were analyzed using H&E, TRAP staining, immunofluorescence, and flow cytometry.
Oral mucosa transcriptome and microbiota were profiled using RNA sequencing and 16S rRNA analysis.

Main Results:

AD induced inflammatory signatures and Th2A-like cell infiltration in oral mucosa.
AD significantly exacerbated periodontitis, with increased severity correlating with dermatitis.
Aggravated periodontitis showed increased macrophage infiltration, CCL3 secretion, and altered oral microbiota.

Conclusions:

Type 2 dermatitis exacerbates periodontitis through specific cellular and microbial alterations.
This study advances the understanding of the interplay between AD and periodontitis.
Findings highlight the importance of considering systemic inflammation in oral health.