Related Experiment Video
Updated: Jul 12, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
[Correlation Between Plasma Trimethylamine N-Oxide and Lipid Levels in Hyperlipidemic Patients]
Tu'erhong Fei'erdun1, Weimin Zhang1, Keyoumu Yilihamujiang1
1Department of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Xinjiang Medical University, Urumuqi 830000, China.
Objective:
To investigate the correlation between the plasma levels of trimethylamine N-oxide (TMAO) and lipid levels in hyperlipidemic patients.
Methods:
A total of 130 patients who received treatment and underwent coronary angiography at the Heart Center, the First Affiliated Hospital of Xinjiang Medical University between March 2019 and March 2021 were enrolled. Patients' plasma TMAO levels were determined by stable isotope liquid chromatography/mass spectrometry. The correlation between plasma TMAO levels and the levels of lipids, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), was analyzed.
Results:
Patients with hyperlipidemia had higher plasma TMAO levels (μmol/L) than patients without hyperlipidemia did (6.73±5.40 vs. 3.82±2.65), with the difference being statistically significant ( P<0.05). After controlling for the effects of age and body mass index, partial correlation analysis revealed that plasma TMAO levels were positively correlated with plasma TG ( r=0.286, P<0.001) and negatively correlated with HDL-C ( r=-0.366, P<0.001).
Conclusion:
There is a correlation between plasma TMAO levels and lipid levels in hyperlipidemic patients.
Related Concept Videos
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Cholesterol: Significance and Regulation
Considering cholesterol and...
Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Atherosclerosis III: Management

